(A) The distribution of all genes across the five categories based on transcript abundance in brain as well as in all other tissues. Regional specific summary pages including lists of regional elavated genes can be found here: cerebral cortex, olfactory bulb, hippocampal formation, amygdala, basal ganglia, thalamus, hypothalamus, midbrain, cerebellum, pons, medulla oblongata, spinal cord as well as white matter and choroid plexus.įigure 2. Out of the genes with regional expression classification, 1064 are categorized as genes with a regionally eleveted expression. Regional classification was based on 17832 genes are detected in the brain and included in all used external datasets. The transcriptome analysis shows that 76% (n= 15331) of all human proteins (n= 20162) are expressed in the brain (based on 14 brain regions, spinal cord and corpus callosum). For the regional classification the brain is divided into 14 anatomically defined regions, color coded in Figure 1. A brain-centric point of view comparing gene expression in the various regions of the brainīrain expression is compared to other organs and tissues by using the highest expression value of all brain regions.
A whole-body perspective, comparing gene expression in the brain to peripheral organ and tissue types.Protein-coding genes are classified based on RNA expression in brain from two different perspectives:
